Description

(2S,3S)-1,2-Epoxy-3-(Cbz-Amino)-4-Phenylbutane is a high-purity chiral epoxide building block of significant importance in asymmetric synthesis. This compound serves as a critical intermediate for the production of complex pharmaceutical molecules, particularly HIV protease inhibitors and other active pharmaceutical ingredients (APIs). It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics.

Application

• Key chiral intermediate in the synthesis of HIV protease inhibitors such as Nelfinavir and Amprenavir.
• Versatile building block for asymmetric synthesis of amino alcohols and other pharmacologically active compounds.
• Critical raw material in pharmaceutical process research and development (PR&D) and scale-up activities.
• Precursor for the preparation of more complex peptidomimetics and enzyme inhibitors.
• Standard reference compound for analytical method development and quality control in API manufacturing.
• Research chemical for academic and industrial studies in organic and medicinal chemistry.

Basic Information

Product Name	(2S,3S)-1,2-Epoxy-3-(Cbz-Amino)-4-Phenylbutane
CAS No.	128018-44-0
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	(2S,3S)-1,2-Epoxy-3-[(benzyloxy)carbonyl]amino-4-phenylbutane; (2S,3S)-N-Cbz-3-Amino-1,2-epoxy-4-phenylbutane; (2S,3S)-3-[(Benzyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; (2S,3S)-Cbz-Amino Epoxide; AG 1776 Epoxide Intermediate; N-[(Benzyloxy)carbonyl]-L-phenylalanine Epoxide; (2S,3S)-1,2-Epoxy-3-(carbobenzyloxyamino)-4-phenylbutane
EINECS	Contact for details

Quality Control

Our (2S,3S)-1,2-Epoxy-3-(Cbz-Amino)-4-Phenylbutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.