Description

(2S,3S)-3-(Benzyloxycarbonylamino)-1-Chloro-2-Hydroxy-4-Phenylbutane is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. This compound is valued for its defined stereochemistry, which is critical for constructing complex molecules with specific biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, including HIV-1 protease inhibitors and renin inhibitors.
• Peptide Chemistry: Used in the construction of modified peptide sequences where the chlorohydrin moiety allows for further functionalization.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis routes due to its two defined stereocenters.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme mechanisms.
• Custom Synthesis: A critical component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(2S,3S)-3-(Benzyloxycarbonylamino)-1-Chloro-2-Hydroxy-4-Phenylbutane
CAS No.	128018-43-9
Molecular Formula	C18H20ClNO4
Molecular Weight	349.81 g/mol
Synonyms	(2S,3S)-1-Chloro-2-hydroxy-3-[(phenylmethoxy)carbonyl]amino]-4-phenylbutane; (2S,3S)-3-[(Benzyloxycarbonyl)amino]-1-chloro-2-hydroxy-4-phenylbutane; (2S,3S)-N-Cbz-3-Amino-1-chloro-2-hydroxy-4-phenylbutane; Cbz-(S,S)-AHPB-Cl; (S,S)-1-Chloro-2-hydroxy-3-(Cbz-amino)-4-phenylbutane; Z-(S,S)-AHPB-Cl; (2S,3S)-1-Chloro-2-hydroxy-4-phenyl-3-[(phenylmethoxy)carbonylamino]butane
EINECS	Contact for details

Quality Control

Our (2S,3S)-3-(Benzyloxycarbonylamino)-1-Chloro-2-Hydroxy-4-Phenylbutane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.