Description

3-Tetrahydropyranyloxycholesta-20(21),24-Diene is a high-purity steroidal intermediate featuring a tetrahydropyranyl (THP) protecting group on the oxygen functionality. This compound is of significant value in synthetic organic chemistry, particularly for the research and development of complex bioactive molecules. It serves as a critical building block for pharmaceutical chemists and researchers in the life sciences sector, enabling the synthesis of novel steroid derivatives and other advanced chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel steroid-based drug candidates and active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial R&D laboratories for exploring new chemical entities and studying structure-activity relationships (SAR).
• Steroid Chemistry: Enables the selective modification of the steroidal backbone, facilitating the introduction of specific functional groups at protected sites.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex target molecules.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays to investigate sterol metabolism and related pathways.

Basic Information

Product Name	3-Tetrahydropyranyloxycholesta-20(21),24-Diene
CAS No.	127650-85-5
Molecular Formula	C32H52O2
Molecular Weight	468.76 g/mol
Synonyms	3-(Tetrahydropyran-2-yloxy)cholesta-20(21),24-diene; Cholesta-20(21),24-dien-3-ol, 3-(tetrahydro-2H-pyran-2-yl) ether; 3-THP-protected cholestadiene; 3β-(Tetrahydropyran-2-yloxy)-cholesta-20(21),24-diene; THP-Cholestadiene; 3-THPO-Cholesta-20(21),24-Diene; Steroid THP ether intermediate
EINECS	Contact for details

Quality Control

Our 3-Tetrahydropyranyloxycholesta-20(21),24-Diene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports research reproducibility and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.