Description

S-(4-Acetylmercaptobut-2-Ynyl)Trimethylammonium is a specialized organic ammonium salt featuring a reactive acetylthio and alkyne functional group. This compound is valued as a key synthetic intermediate and building block in advanced organic and medicinal chemistry. It is primarily required by research institutions and pharmaceutical development companies for the synthesis of novel bioactive molecules, including potential enzyme inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting enzyme active sites via covalent modification.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics, leveraging its reactive handles for site-specific labeling.
• Chemical Biology Probes: Serves as a precursor for activity-based probes (ABPs) used to study enzyme function and mechanism in complex biological systems.
• Material Science Research: Employed in the synthesis of functionalized polymers or surfaces with specific ionic or reactive properties.
• Agrochemical Development: Acts as an intermediate in the research and synthesis of new crop protection agents with novel modes of action.

Basic Information

Product Name	S-(4-Acetylmercaptobut-2-Ynyl)Trimethylammonium
CAS No.	127628-84-6
Molecular Formula	C10H18NOS+ (typically as an iodide or other salt)
Molecular Weight	200.32 g/mol (for the cation)
Synonyms	4-(Acetylthio)-2-butyn-1-yltrimethylammonium; 4-(Acetylsulfanyl)but-2-yn-1-yl-trimethylazanium; Trimethyl-[4-(acetylthio)but-2-ynyl]ammonium; S-(4-Trimethylammoniobut-2-ynyl) thioacetate; Acetylthiocholine alkyne analog; 2-Butyn-1-yltrimethylammonium, 4-(acetylthio)-
EINECS	Contact for details

Quality Control

Our S-(4-Acetylmercaptobut-2-Ynyl)Trimethylammonium is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed using advanced techniques including NMR and HPLC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere after each use to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.