Description

n-[(3S,4R)-6-Cyano-3,4-Dihydro-3-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-4-Yl]-n-Hydroxyacetamide CAS NO 127408-31-5 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise molecular architecture is required for efficacy. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring chiral building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of proprietary drug candidates.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients, especially in oncology and central nervous system (CNS) targeted therapies.
• Chemical Biology Research: Employed as a molecular probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Integral to scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-[(3S,4R)-6-Cyano-3,4-Dihydro-3-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-4-Yl]-n-Hydroxyacetamide
CAS No.	127408-31-5
Molecular Formula	C14H16N2O4
Molecular Weight	276.29 g/mol
Synonyms	6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl hydroxyacetamide; (3S,4R)-4-(Hydroxyamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile; N-Hydroxy-2-[(3S,4R)-3-hydroxy-2,2-dimethyl-6-cyano-3,4-dihydro-2H-chromen-4-yl]acetamide; Chroman-4-yl acetamide derivative; CAS 127408-31-5
EINECS	Contact for details

Quality Control

Our n-[(3S,4R)-6-Cyano-3,4-Dihydro-3-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-4-Yl]-n-Hydroxyacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and residual solvent levels is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (3S,4R)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.