Description

Sodium:2-Fluorobenzenesulfinate CAS NO 127159-66-4 is a high-purity organosulfur compound, specifically the sodium salt of 2-fluorobenzenesulfinic acid. This specialty chemical serves as a versatile and critical building block in advanced organic synthesis, particularly for introducing the fluorinated benzenesulfonyl moiety. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and other drug candidates, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides where the fluorobenzenesulfinate group contributes to efficacy and environmental profile.
• Material Science & Polymer Chemistry: Employed as a monomer or modifying agent for creating specialty polymers, liquid crystals, and advanced materials with specific electronic or surface properties.
• Cross-Coupling Reactions: Acts as a competent reagent in transition-metal-catalyzed cross-coupling reactions (e.g., with palladium or copper) to form carbon-sulfur bonds.
• Sulfone and Sulfonamide Preparation: Serves as a direct starting material for the preparation of various sulfones and sulfonamides through oxidation or amidation pathways.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process R&D for exploring new chemical entities and optimizing synthetic routes.

Basic Information

Product Name	Sodium:2-Fluorobenzenesulfinate
CAS No.	127159-66-4
Molecular Formula	C6H4FNaO2S
Molecular Weight	182.15 g/mol
Synonyms	Sodium 2-Fluorobenzenesulfinate; 2-Fluorobenzenesulfinic Acid Sodium Salt; Benzenesulfinic Acid, 2-Fluoro-, Sodium Salt; o-Fluorobenzenesulfinic Acid Sodium Salt; Sodium o-Fluorobenzenesulfinate; 2-Fluorophenylsulfinic Acid Sodium Salt; Sodium (2-Fluorophenyl)sulfinate
EINECS	Contact for details

Quality Control

Our Sodium:2-Fluorobenzenesulfinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.