Description

Dihydro-3-Hydroxy-5,5-Dimethyl-3-(Trifluoromethyl)-2(3H)-Furanone is a high-value fluorinated heterocyclic building block with significant synthetic utility. Its core value lies in the trifluoromethyl group, which imparts unique physicochemical properties to target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated segments.
• Organic Synthesis Reagent: Employed in asymmetric synthesis and catalysis research as a chiral auxiliary or to introduce sterically demanding fluorinated motifs.
• Flavor & Fragrance Chemistry: Potential intermediate for creating novel, high-value aroma chemicals with unique organoleptic properties.

Basic Information

Product Name	Dihydro-3-Hydroxy-5,5-Dimethyl-3-(Trifluoromethyl)-2(3H)-Furanone
CAS No.	126953-88-6
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	5,5-Dimethyl-3-(trifluoromethyl)dihydrofuran-2,3-dione; 3-Hydroxy-5,5-dimethyl-3-(trifluoromethyl)dihydrofuran-2(3H)-one; 3-Trifluoromethyl-5,5-dimethyl-3-hydroxydihydrofuran-2-one; 2(3H)-Furanone, dihydro-3-hydroxy-5,5-dimethyl-3-(trifluoromethyl)-; TFMB Lactone; HFC-365 Lactone Intermediate
EINECS	Contact for details

Quality Control

Our production of Dihydro-3-Hydroxy-5,5-Dimethyl-3-(Trifluoromethyl)-2(3H)-Furanone adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and compliance with client specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.