Description

(2R)-1-(2,4-Difluorophenyl)-2-(Tetrahydro-2H-Pyran-2-Yloxy)Propan-1-One is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for constructing complex active pharmaceutical ingredients (APIs), particularly those targeting fungal and bacterial infections. This compound is essential for research institutions and manufacturers in the pharmaceutical industry who require enantiomerically pure intermediates for the development of new therapeutic agents and generic drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of advanced antifungal and antibacterial agents.
• API Development: Used in research and process development for novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a precursor in catalytic asymmetric reactions to introduce stereochemical complexity.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for target molecules.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of client-specific drug substances.
• Academic & Industrial Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(2R)-1-(2,4-Difluorophenyl)-2-(Tetrahydro-2H-Pyran-2-Yloxy)Propan-1-One
CAS No.	126918-17-0
Molecular Formula	C14H16F2O3
Molecular Weight	270.27 g/mol
Synonyms	(R)-1-(2,4-Difluorophenyl)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-one; (2R)-1-(2,4-Difluorophenyl)-2-(THP-Oxy)propan-1-one; 2,4-Difluoro-(R)-α-(tetrahydro-2-pyranyloxy)acetophenone; (R)-THP-Protected 2,4-Difluorophenyl Glycidyl Ketone Derivative; 126918-17-0; (R)-Enantiomer of DFPP-THP; Chiral Difluorophenyl THP Ether Ketone
EINECS	Contact for details

Quality Control

Our (2R)-1-(2,4-Difluorophenyl)-2-(Tetrahydro-2H-Pyran-2-Yloxy)Propan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.