Description

1-(Mesitylsulfonyl)Pyrrolidine-2-Carboxylic Acid is a specialized pyrrolidine derivative featuring a mesitylsulfonyl protecting group, making it a valuable intermediate in advanced organic synthesis. Its primary commercial value lies in its role as a key building block for the development of pharmaceuticals and bioactive compounds, particularly in medicinal chemistry research. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on creating novel therapeutic agents, peptidomimetics, and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Peptidomimetic Scaffold: Serves as a constrained proline analog for designing and synthesizing novel peptide-like molecules with enhanced stability and bioavailability.
• Medicinal Chemistry Research: Used extensively in drug discovery programs as a versatile building block for constructing compound libraries and probing structure-activity relationships (SAR).
• Organocatalyst Synthesis: Acts as a precursor for developing novel chiral organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	1-(Mesitylsulfonyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	126522-74-5
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	1-[(2,4,6-Trimethylphenyl)sulfonyl]-L-proline; 1-Mesitylsulfonyl-L-proline; (S)-1-(Mesitylsulfonyl)pyrrolidine-2-carboxylic acid; 1-(2,4,6-Trimethylbenzenesulfonyl)pyrrolidine-2-carboxylic acid; L-Proline, 1-[(2,4,6-trimethylphenyl)sulfonyl]-; Mesitylsulfonylproline; Ms-Pro-OH; 1-Ms-Proline
EINECS	Contact for details

Quality Control

Our 1-(Mesitylsulfonyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.