Description

Ethyl 5-Tributylstannanylisoxazole-3-Carboxylate is a specialized organotin compound that serves as a critical building block in advanced organic synthesis. Its value lies in its unique reactivity, particularly in Stille cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science sectors, where it is used to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing isoxazole or complex heterocyclic cores for therapeutic applications.
• Stille Cross-Coupling Reagent: Facilitates carbon-carbon bond formation between stannanes and organic halides or triflates, crucial for constructing complex molecular architectures in medicinal chemistry.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the isoxazole moiety can impart specific biological activity.
• Material Science & Organic Electronics: Serves as a building block for creating organic semiconductors, light-emitting materials, and other functional polymers.
• Chemical Synthesis & Process Development: Employed in route scouting and scale-up for the production of high-value fine chemicals and complex natural product analogs.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new chemical spaces in synthetic organic chemistry laboratories.

Basic Information

Product Name	Ethyl 5-Tributylstannanylisoxazole-3-Carboxylate
CAS No.	126085-91-4
Molecular Formula	C20H37NO3Sn
Molecular Weight	482.22 g/mol
Synonyms	Ethyl 5-(Tributylstannyl)isoxazole-3-carboxylate; 3-Isoxazolecarboxylic acid, 5-(tributylstannyl)-, ethyl ester; 5-Tributylstannyl-3-isoxazolecarboxylic acid ethyl ester; Tributyl(3-ethoxycarbonylisoxazol-5-yl)stannane; Ethyl 5-(tributyltin)isoxazole-3-carboxylate; 5-(Tributylstannyl)isoxazole-3-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Tributylstannanylisoxazole-3-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C), HPLC, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Tin (Sn) Content	24.0 - 25.0 %
Water Content (KF)	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.