Description

tert-Butyl (S)-(6-Oxotetrahydro-2H-Pyran-3-Yl)Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound is essential for the stereoselective synthesis of complex molecules, offering a protected amine functionality and a versatile lactone moiety for further derivatization. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Asymmetric Synthesis: Serves as a critical starting material or intermediate in asymmetric catalytic processes and chiral pool syntheses to introduce defined stereocenters.
• Protease Inhibitor Research: Used in the research and development of protease inhibitors, where the lactone and carbamate groups are common pharmacophores.
• Peptidomimetics & Conformationally Restricted Peptides: The tetrahydro-2H-pyran scaffold is valuable for constructing peptidomimetics and constraining peptide backbone geometry to enhance stability and bioavailability.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore and optimize the biological activity of lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chemical and enantiomeric purity.

Basic Information

Product Name	tert-Butyl (S)-(6-Oxotetrahydro-2H-Pyran-3-Yl)Carbamate
CAS No.	125982-23-2
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	(S)-tert-Butyl 6-oxotetrahydro-2H-pyran-3-ylcarbamate; (3S)-6-Oxooxan-3-yl N-tert-butylcarbamate; (S)-3-((tert-Butoxycarbonyl)amino)dihydro-2H-pyran-6(3H)-one; (S)-3-(Boc-amino)-6-valerolactone; (S)-3-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-6-one; tert-Butyl (S)-6-oxotetrahydro-2H-pyran-3-ylcarbamate; (S)-Boc-3-aminodihydro-2H-pyran-6(3H)-one
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-(6-Oxotetrahydro-2H-Pyran-3-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and standard purity assays. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.