Description

N,N,N',N'-Tetramethyl-o-(3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl)Uronium Tetrafluoroborate is a highly reactive peptide coupling reagent, specifically an uronium salt activator. This compound is critical for facilitating efficient amide bond formation in solid-phase peptide synthesis (SPPS) and solution-phase chemistry, offering advantages in coupling speed and reduced racemization. It is an essential raw material for pharmaceutical R&D, biotechnology, and fine chemical synthesis, particularly in the production of complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key coupling reagent for the efficient assembly of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: For the synthesis of peptides and peptide fragments in liquid media.
• Pharmaceutical Intermediate Production: In the synthesis of active pharmaceutical ingredients (APIs) with peptide backbones.
• Bioconjugation: For coupling peptides to other molecules, such as proteins, dyes, or polymers.
• Research & Development: Used in academic and industrial labs for developing novel peptide-based therapeutics and diagnostics.
• Combinatorial Chemistry: For the rapid generation of peptide libraries for drug discovery screening.

Basic Information

Product Name	N,N,N',N'-Tetramethyl-o-(3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl)Uronium Tetrafluoroborate
CAS No.	125700-69-8
Molecular Formula	C13H18BF4N5O
Molecular Weight	339.12 g/mol
Synonyms	TDBTU; TDBT-U; 3-(H-1,2,3-Benzotriazin-4(3H)-one-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; TDBT-Uronium Tetrafluoroborate; 1,1,3,3-Tetramethyl-2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium Tetrafluoroborate; Benzotriazol-1-yl-1,1,3,3-tetramethyluronium Tetrafluoroborate derivative; Coupling Reagent TDBTU; Peptide Coupling Agent 125700-69-8
EINECS	Contact for details

Quality Control

Our N,N,N',N'-Tetramethyl-o-(3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-Yl)Uronium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as in a glovebox or desiccator, to maintain stability and reactivity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.