Description

tert-Butyl (4R-Cis)-6-Formaldehydel-2,2-Dimethyl-1,3-Dioxane-4-Acetate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and protected functional groups make it a critical precursor for the synthesis of complex, biologically active molecules. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Process Chemistry: Serves as a critical raw material in the development and optimization of scalable commercial manufacturing routes for target molecules.
• Medicinal Chemistry Research: Used in the discovery phase to create novel compound libraries and explore structure-activity relationships (SAR).
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	tert-Butyl (4R-Cis)-6-Formaldehydel-2,2-Dimethyl-1,3-Dioxane-4-Acetate
CAS No.	124752-23-4
Molecular Formula	C13H22O5
Molecular Weight	258.31 g/mol
Synonyms	(4R-cis)-6-Formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; tert-Butyl (4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetate; (4R,6S)-6-Formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester; (R)-tert-Butyl 6-formyl-2,2-dimethyl-1,3-dioxane-4-acetate; (4R-cis)-tert-Butyl 6-formyl-2,2-dimethyl-1,3-dioxane-4-carboxylate (common misnomer); Chiral dioxane acetate aldehyde; 124752-23-4
EINECS	Contact for details

Quality Control

Our tert-Butyl (4R-Cis)-6-Formaldehydel-2,2-Dimethyl-1,3-Dioxane-4-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.