Description

1-[(2R,3S)-2-(2,4-Difluoro-Phenyl)-3-Methyl-Oxiranylmethyl]-1H-[1,2,4]Triazole CAS NO 124627-86-7 is a high-purity, stereochemically defined triazole derivative featuring a 2,4-difluorophenyl and an epoxide (oxirane) functional group. This compound is a critical chiral intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly triazole-based antifungal agents. It is essential for pharmaceutical R&D and manufacturing organizations seeking to develop or produce potent, targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of advanced triazole antifungal APIs, such as those in the azole class.
• Antifungal Drug Development: Used in research and production of systemic and topical antifungal medications targeting fungal lanosterol 14α-demethylase.
• Chemical Synthesis: Serves as a versatile precursor in organic synthesis for introducing the difluorophenyl-oxiranylmethyl-triazole moiety into more complex molecules.
• Agrochemical Research: Potential intermediate in the development of novel fungicides for crop protection, leveraging its specific bioactive structure.
• Biochemical Tool Compound: Used in biochemical assays and studies to investigate enzyme inhibition mechanisms related to sterol biosynthesis.

Basic Information

Product Name	1-[(2R,3S)-2-(2,4-Difluoro-Phenyl)-3-Methyl-Oxiranylmethyl]-1H-[1,2,4]Triazole
CAS No.	124627-86-7
Molecular Formula	C12H11F2N3O
Molecular Weight	251.23 g/mol
Synonyms	(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane; (2R,3S)-Epoxiconazole Intermediate; (2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol epoxide; (2R,3S)-Difenoconazole Key Intermediate; 1H-1,2,4-Triazole, 1-[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-; (R,S)-Syn Epoxy Triazole Derivative
EINECS	Contact for details

Quality Control

Our 1-[(2R,3S)-2-(2,4-Difluoro-Phenyl)-3-Methyl-Oxiranylmethyl]-1H-[1,2,4]Triazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, to ensure compliance with stringent pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.