Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Aminophenyl)Methyl]- is a bifunctional chelating agent, a key intermediate for creating targeted diagnostic and therapeutic agents. Its core value lies in its ability to strongly bind metal ions like gadolinium or lutetium while providing a reactive site for conjugation to targeting biomolecules such as antibodies or peptides. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation radiopharmaceuticals and MRI contrast agents.

Application

• Radiopharmaceutical Precursor: Conjugation to targeting vectors (e.g., peptides, antibodies) for Positron Emission Tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Therapeutic Radiopharmaceuticals: Used in the synthesis of targeted radioligand therapies (RLT), particularly for binding therapeutic isotopes like Lutetium-177 or Actinium-225.
• MRI Contrast Agent Intermediate: Chelation of Gadolinium (Gd³⁺) to create high-relaxivity, targeted magnetic resonance imaging (MRI) contrast agents.
• Bifunctional Chelator (BFC) Research: A critical tool in academic and industrial research for studying metal complexation, pharmacokinetics, and novel diagnostic/therapeutic platforms.
• Molecular Imaging Probe Development: Building block for creating multimodal imaging probes that combine different diagnostic techniques.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Aminophenyl)Methyl]-
CAS No.	123317-52-2
Molecular Formula	C26H36N6O8
Molecular Weight	560.60 g/mol
Synonyms	p-NH2-Bn-DOTA; DOTA-(aniline); 2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; 4-Aminobenzyl-DOTA; DOTA-amine; DOTA-NH2; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(4-aminobenzyl)amide; AB-DOTA
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-[(4-Aminophenyl)Methyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.