Description

Benzene, 1-(Bromomethyl)-4-Chloro-2-Methyl- is a halogenated aromatic compound that serves as a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both bromomethyl and chloro substituents on a methylbenzene core, makes it a valuable electrophile for introducing functionalized benzyl groups. This intermediate is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials who require reliable, high-purity raw materials to ensure reaction efficiency and final product quality.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly for introducing substituted benzyl motifs.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, where its halogenated structure allows for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers requiring specific aromatic architectures.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological mechanisms and target engagement.
• Custom Synthesis and Scale-up: A fundamental substrate for contract research and manufacturing organizations (CROs/CMOs) performing custom synthesis from milligram to kilogram scale.

Basic Information

Product Name	Benzene, 1-(Bromomethyl)-4-Chloro-2-Methyl-
CAS No.	122488-73-7
Molecular Formula	C9H10BrCl
Molecular Weight	233.53 g/mol
Synonyms	4-Chloro-2-methylbenzyl bromide; 1-(Bromomethyl)-4-chloro-2-methylbenzene; (4-Chloro-2-methylphenyl)methyl bromide; 2-Methyl-4-chlorobenzyl bromide; α-Bromo-4-chloro-2-methyltoluene; 4-Chloro-α-bromo-2-methyltoluene; p-Chloro-o-methylbenzyl bromide
EINECS	Contact for details

Quality Control

Our Benzene, 1-(Bromomethyl)-4-Chloro-2-Methyl- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters, supporting your regulatory and R&D requirements. Our commitment to consistent quality and supply chain transparency ensures you receive a reliable intermediate for your most demanding syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.