Description

2-(Methylsulfonyl)-5-(Tributylstannyl)Pyrimidine is a high-value organotin intermediate featuring a reactive pyrimidine core functionalized with both a methylsulfonyl and a tributylstannyl group. This unique structure makes it a critical building block for cross-coupling reactions, particularly in Stille-type couplings, enabling the precise synthesis of complex heterocyclic systems. It is essential for researchers and manufacturers in pharmaceutical development and advanced material science who require reliable, high-purity reagents for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer agents containing pyrimidine scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides that leverage its heterocyclic structure.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as OLEDs and semiconductors, via polymerization or cross-coupling.
• Stille Cross-Coupling Reactions: The tributylstannyl group is pivotal for forming carbon-carbon bonds with aryl or vinyl halides under palladium catalysis, facilitating complex molecule assembly.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Product Name	2-(Methylsulfonyl)-5-(Tributylstannyl)Pyrimidine
CAS No.	122476-85-1
Molecular Formula	C₁₇H₃₂N₂O₂SSn
Molecular Weight	455.22 g/mol
Synonyms	5-(Tributylstannyl)-2-(methylsulfonyl)pyrimidine; 2-Methylsulfonyl-5-tributylstannylpyrimidine; Tributyl[5-(methylsulfonyl)-2-pyrimidinyl]stannane; 2-Pyrimidinesulfonic acid, 5-(tributylstannyl)-, methyl ester; Stannane, tributyl[5-(methylsulfonyl)-2-pyrimidinyl]-; 2-(Methanesulfonyl)-5-(tributylstannyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(Methylsulfonyl)-5-(Tributylstannyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when possible to maximize shelf-life stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Tin (Sn) Content	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.