Description

Dimethyl L-Isothiocyanatosuccinate is a specialized chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly those containing heterocyclic and peptidomimetic structures. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of chiral heterocycles and constrained amino acid analogs for drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive isothiocyanate group.
• Peptidomimetic Research: Serves as a building block for creating non-peptide compounds that mimic peptide structure and function.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce chiral centers into target molecules.
• Material Science Research: Investigated as a monomer or cross-linking agent for specialized polymer applications.

Basic Information

Product Name	Dimethyl L-Isothiocyanatosuccinate
CAS No.	121928-38-9
Molecular Formula	C7H9NO4S
Molecular Weight	203.21 g/mol
Synonyms	L-Aspartic acid, N-isothiocyanato-, dimethyl ester; (S)-Dimethyl 2-isothiocyanatosuccinate; Dimethyl (2S)-2-isothiocyanatobutanedioate; N-Isothiocyanato-L-aspartic acid dimethyl ester; L-Isothiocyanatosuccinic acid dimethyl ester; NSC 332008
EINECS	Contact for details

Quality Control

Our Dimethyl L-Isothiocyanatosuccinate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.