Description

Methylglyoxal Bis(3-Aminopropylamidinohydrazone) is a specialized polyfunctional organic compound with significant biochemical and industrial relevance. Its core value lies in its potent ability to act as a cross-linking agent and a specific inhibitor of polyamine biosynthesis, making it a critical research tool and process intermediate. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors. Its unique structure facilitates applications ranging from enzyme inhibition studies to the synthesis of novel polymers and chelating agents.

Application

• Biochemical Research: Used as a specific inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in polyamine biosynthesis pathways, for studying cell proliferation and differentiation.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of novel therapeutic agents targeting cancer, parasitic diseases, and other conditions linked to polyamine metabolism.
• Cross-linking Agent: Employed in the modification of proteins, enzymes, and other biomolecules to study structure-function relationships or to create stabilized biocatalysts.
• Polymer Chemistry: Acts as a monomer or cross-linker in the production of specialty polymers, resins, and hydrogels with tailored mechanical and chemical properties.
• Chelating Agent Synthesis: Utilized as a precursor for synthesizing advanced chelating ligands with high affinity for specific metal ions, useful in catalysis or metal sequestration.
• Agricultural Chemistry: Investigated for the development of plant growth regulators or agents that modulate metabolic pathways in crops.

Basic Information

Product Name	Methylglyoxal Bis(3-Aminopropylamidinohydrazone)
CAS No.	121496-63-7
Molecular Formula	C10H24N8O2
Molecular Weight	288.35 g/mol
Synonyms	MGBG; Methyl-GAG; Methylglyoxal Bis(guanylhydrazone); Mitoguazone; Methylglyoxal Bis(amidinohydrazone); NSC-32946; 1,1'-[(Methylethanediylidene)dinitrilo]diguanidine; Methylglyoxal Bis(3-Aminopropylamidinohydrazone) Dihydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our production of Methylglyoxal Bis(3-Aminopropylamidinohydrazone) adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for research and industrial use. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles to meet the exacting standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.