Description

cis-Azetidine-2,4-Dicarboxylic Acid is a conformationally restricted dicarboxylic acid derivative of the azetidine heterocycle, serving as a key chiral building block and a constrained analogue of glutamic acid. This compound is of significant value in advanced pharmaceutical research and organic synthesis, where its rigid, four-membered ring structure is utilized to modulate biological activity and explore novel structure-activity relationships. It is primarily needed by medicinal chemists and researchers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a constrained bioisostere for glutamic acid in the design and development of glutamate receptor modulators (e.g., for NMDA or AMPA receptors).
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides or plant growth regulators with enhanced stability.
• Peptidomimetics: Incorporated into peptide chains to induce specific conformational constraints and improve metabolic stability.
• Ligand Development: Utilized in the creation of specialized chelating agents or catalysts for asymmetric synthesis.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme mechanisms or receptor-ligand interactions involving dicarboxylate motifs.

Basic Information

Product Name	cis-Azetidine-2,4-Dicarboxylic Acid
CAS No.	121050-04-2
Molecular Formula	C5H7NO4
Molecular Weight	145.11 g/mol
Synonyms	(2S,4S)-Azetidine-2,4-dicarboxylic acid; (2S,4S)-2,4-Dicarboxyazetidine; L-cis-2,4-Dicarboxyazetidine; cis-2,4-Azetidinedicarboxylic Acid; Azetidine-2,4-dicarboxylic acid, cis-; L-Azetidine-2,4-dicarboxylic acid; A constrained glutamic acid analogue
EINECS	Contact for details

Quality Control

Our cis-Azetidine-2,4-Dicarboxylic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.