Description

2-Acetyl-T-Butyl-Dimethylsilyl-Phenol is a specialized organosilicon-protected phenolic compound, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in its dual functionality, where the silyl group acts as a robust protecting agent for the phenolic hydroxyl, enabling selective reactions in complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel organic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially where selective protection of phenolic groups is required.
• Fine Chemical Synthesis: Used in the production of specialty chemicals, agrochemicals, and advanced materials.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for constructing complex molecular architectures.
• Protecting Group Chemistry: The *tert*-butyldimethylsilyl (TBDMS) group provides stability under a wide range of reaction conditions, making it ideal for multi-step synthetic sequences.
• Ligand and Catalyst Development: Potential precursor for creating novel ligands or organocatalysts in asymmetric synthesis.

Basic Information

Product Name	2-Acetyl-T-Butyl-Dimethylsilyl-Phenol
CAS No.	120820-40-8
Molecular Formula	C₁₄H₂₂O₂Si
Molecular Weight	250.41 g/mol
Synonyms	2'-Hydroxyacetophenone TBDMS Ether; 1-[2-[(tert-Butyldimethylsilyl)oxy]phenyl]ethan-1-one; 2-Acetylphenol tert-butyldimethylsilyl ether; 2'-TBDMS-oxyacetophenone; o-Acetylphenol TBDMS ether; 2-(tert-Butyldimethylsilyloxy)acetophenone; 2-Hydroxyacetophenone O-TBDMS; 120820-40-8
EINECS	Contact for details

Quality Control

Our 2-Acetyl-T-Butyl-Dimethylsilyl-Phenol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.