Description

(R)-3-[(p-Toluenesulfonyl)Oxy]Tetrahydrothiophene is a high-purity chiral sulfonate ester intermediate of significant importance in asymmetric synthesis. This compound matters as a key building block for the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, enabling precise stereochemical control. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex sulfur-containing molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of sulfur-containing drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides with specific stereochemical activity.
• Catalyst & Ligand Development: Serves as a precursor for novel chiral catalysts and ligands used in transition metal catalysis and organocatalysis.
• Asymmetric Synthesis: Employed in stereoselective carbon-sulfur bond-forming reactions to create enantiomerically pure compounds.
• Chemical Research: A valuable tool in academic and industrial research for exploring new synthetic methodologies and reaction pathways.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.

Basic Information

Product Name	(R)-3-[(p-Toluenesulfonyl)Oxy]Tetrahydrothiophene
CAS No.	120735-09-3
Molecular Formula	C11H14O3S2
Molecular Weight	258.36 g/mol
Synonyms	(R)-Tetrahydrothiophen-3-yl 4-methylbenzenesulfonate; (R)-3-(Tosyloxy)tetrahydrothiophene; (R)-THT-OTs; (3R)-3-[(4-Methylphenyl)sulfonyl]oxy]thiolane; (R)-3-Hydroxytetrahydrothiophene Tosylate; (R)-Tetrahydro-3-thiophenyl Tosylate; (R)-3-Tosyloxytetrahydrothiophene; (R)-3-TsO-Tetrahydrothiophene
EINECS	Contact for details

Quality Control

Our (R)-3-[(p-Toluenesulfonyl)Oxy]Tetrahydrothiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.