Description

2-Chloro-4-Methanesulfonyl-3-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid is a high-value, multi-functional organic intermediate with a complex molecular architecture designed for advanced synthesis. Its core value proposition lies in its role as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated fluorine-containing motifs. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries who are focused on creating next-generation compounds with enhanced efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides and fungicides, leveraging the trifluoroethoxy group for improved biological activity and environmental profile.
• Material Science Research: Used in the development of specialty polymers and liquid crystals, where its unique benzoic acid derivative structure can impart specific electronic or self-assembly properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways due to its reactive carboxylic acid and sulfonyl groups.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Chloro-4-Methanesulfonyl-3-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid
CAS No.	120100-77-8
Molecular Formula	C12H12ClF3O5S
Molecular Weight	360.73 g/mol
Synonyms	2-Chloro-4-(methylsulfonyl)-3-[(2,2,2-trifluoroethoxy)methyl]benzoic acid; Benzoic acid, 2-chloro-4-(methylsulfonyl)-3-[(2,2,2-trifluoroethoxy)methyl]-; 3-[(2,2,2-Trifluoroethoxy)methyl]-2-chloro-4-(methylsulfonyl)benzoic acid; 2-Chloro-4-methanesulphonyl-3-[(2,2,2-trifluoroethoxy)methyl]benzoic acid; CAS 120100-77-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Methanesulfonyl-3-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, ensuring supply chain integrity and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.