Description

18-Crown-6 2,3,11,12-Tetracarboxylic Acid is a highly functionalized derivative of the classic 18-crown-6 ether, featuring four carboxylic acid groups strategically positioned on the macrocyclic ring. This unique structure makes it an exceptionally versatile and powerful chelating agent and phase-transfer catalyst for binding and transporting metal cations, particularly alkali and alkaline earth metals. It is a critical building block and reagent for researchers and manufacturers in advanced material science, supramolecular chemistry, and pharmaceutical synthesis who require precise molecular recognition and controlled ion transport.

Application

• Supramolecular Chemistry & Host-Guest Systems: Serves as a key precursor for constructing complex molecular machines, sensors, and switchable systems due to its pre-organized binding sites.
• Advanced Material Synthesis: Used as a functional monomer or cross-linker for creating ion-selective polymers, membranes, and smart materials with tailored transport properties.
• Catalysis & Organic Synthesis: Acts as a highly effective phase-transfer catalyst for reactions involving alkali metal salts in biphasic systems, enhancing reaction rates and yields.
• Analytical Chemistry & Sensor Development: Employed in the design of ion-selective electrodes (ISEs) and fluorescent sensors for the detection of specific metal ions.
• Pharmaceutical Intermediates: Utilized in the synthesis of specialized drug candidates where controlled ion binding or delivery is required.
• Metal Ion Separation & Extraction: Applied in processes for the selective separation, recovery, or purification of valuable or toxic metal ions from complex mixtures.

Basic Information

Product Name	18-Crown-6 2,3,11,12-Tetracarboxylic Acid
CAS No.	119719-58-3
Molecular Formula	C20H28O14
Molecular Weight	492.43 g/mol
Synonyms	2,3,11,12-Tetracarboxy-18-crown-6; 18-Crown-6-2,3,11,12-tetracarboxylic Acid; 1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3,11,12-tetracarboxylic Acid; 18C6-TCA; Tetra-acid functionalized 18-crown-6; Dicyclohexano-18-crown-6-tetracarboxylic acid (related structural isomer); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 18-Crown-6 2,3,11,12-Tetracarboxylic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation of quality. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.