Description

Silylated Erythromycin Oxime Ketal CAS NO 119665-76-8 is a key protected intermediate in the synthesis of advanced macrolide antibiotics. This compound is critical for researchers and manufacturers developing next-generation antibacterial agents with improved stability and efficacy. It is primarily utilized by the pharmaceutical industry for the research and production of novel erythromycin derivatives and other complex therapeutic molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel semisynthetic macrolide antibiotics.
• Antibacterial Drug Development: Used in R&D for creating new derivatives with enhanced pharmacokinetic properties and reduced bacterial resistance.
• Chemical Synthesis: Serves as a protected precursor for further selective functionalization of the erythromycin core structure.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for advanced antibiotic APIs.
• Academic & Institutional Research: A valuable reagent for studying macrolide structure-activity relationships and mechanism of action.

Basic Information

Product Name	Silylated Erythromycin Oxime Ketal
CAS No.	119665-76-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Erythromycin, 9-[O-[(1,1-dimethylethyl)dimethylsilyl]oxime], 6,9;12,13-bis-O-(1-methylethylidene) ketal; 6,9:12,13-Bis-O-(1-methylethylidene)-9-[O-[(1,1-dimethylethyl)dimethylsilyl]oxime]erythromycin; Erythromycin A 9-[(tert-Butyldimethylsilyl)oxime] 6,9;12,13-bisacetal; TBDMS Erythromycin Oxime Ketal; tert-Butyldimethylsilyl Erythromycin Oxime Ketal
EINECS	Contact for details

Quality Control

Our Silylated Erythromycin Oxime Ketal is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.