Description

N,N',N'',N'''-Tetrakis(2-Hydroxypropyl)-1,4,7,10-Tetraazacyclododecane is a functionalized macrocyclic polyamine derivative, specifically a cyclen-based chelating agent modified with hydroxypropyl arms. This molecular structure provides excellent metal ion binding capabilities, making it a crucial intermediate for synthesizing advanced contrast agents and radiopharmaceuticals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, diagnostic imaging, and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of gadolinium-based MRI contrast agents (e.g., Gadoteridol analogs).
• Radiopharmaceuticals: Chelator for radiolabeling with isotopes like Gallium-68 or Copper-64 for PET imaging.
• Catalyst Ligand: Serves as a ligand in homogeneous catalysis for organic synthesis.
• Chemical Research: Building block for developing novel macrocyclic compounds and metal complexes.
• Diagnostic Reagents: Component in the formulation of in-vitro diagnostic kits requiring specific metal chelation.
• Material Science: Used in the development of functionalized polymers and surfaces for metal ion capture.

Basic Information

Product Name	N,N',N'',N'''-Tetrakis(2-Hydroxypropyl)-1,4,7,10-Tetraazacyclododecane
CAS No.	119167-08-7
Molecular Formula	C28H60N4O4
Molecular Weight	516.80 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(2-propanol); HP-DO3A; HP-DO3A Intermediate; Tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane; 1,4,7,10-Tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane; THP-Cyclen; HP-Cyclen; DO3A-HP
EINECS	Contact for details

Quality Control

Our N,N',N'',N'''-Tetrakis(2-Hydroxypropyl)-1,4,7,10-Tetraazacyclododecane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.