Description

(4R)-Tetrahydro-4α-Hydroxy-6α-[(E)-4,4-Bis(4-Fluorophenyl)-3-(1-Methyl-1H-Tetrazol-5-Yl)-1,3-Butadienyl]-2H-Pyran-2-One CAS NO 118845-59-3 is a high-purity, structurally complex organic compound featuring a pyranone core with fluorinated aryl and tetrazole substituents. This compound is a critical advanced pharmaceutical intermediate valued for its role in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation therapeutic agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the research and development of new drug candidates, particularly in areas targeting complex diseases.
• Precursor for Active Pharmaceutical Ingredients (APIs): Used in multi-step synthetic routes to construct the core scaffold of target molecules in medicinal chemistry programs.
• Chemical Biology Research: Employed as a probe or tool compound in biochemical assays to study enzyme interactions or cellular pathways due to its specific structural motifs.
• Process Development and Scale-Up: Supplied to contract development and manufacturing organizations (CDMOs) for optimizing synthetic routes from laboratory to pilot and commercial scale.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(4R)-Tetrahydro-4α-Hydroxy-6α-[(E)-4,4-Bis(4-Fluorophenyl)-3-(1-Methyl-1H-Tetrazol-5-Yl)-1,3-Butadienyl]-2H-Pyran-2-One
CAS No.	118845-59-3
Molecular Formula	C24H21F2N5O3
Molecular Weight	465.45 g/mol
Synonyms	(4R)-Tetrahydro-4α-hydroxy-6α-[(1E)-4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadien-1-yl]-2H-pyran-2-one; 4R-Tetrahydro-4α-hydroxy-6α-[(E)-4,4-bis(4-fluorophenyl)-3-(1-methyltetrazol-5-yl)-1,3-butadienyl]-2H-pyran-2-one; CAS 118845-59-3; 118845-59-3; (4R)-Tetrahydro-4alpha-hydroxy-6alpha-[(E)-4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-2H-pyran-2-one; (4R)-4α-Hydroxy-6α-[(E)-4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]tetrahydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our (4R)-Tetrahydro-4α-Hydroxy-6α-[(E)-4,4-Bis(4-Fluorophenyl)-3-(1-Methyl-1H-Tetrazol-5-Yl)-1,3-Butadienyl]-2H-Pyran-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.