Description

(S)-(+)-Glycidyl-4-Nitrobenzenesulfonate is a high-purity chiral building block and electrophilic reagent. This compound is valued for its role in the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for introducing chiral glycidyl moieties into target structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially β-blockers and other cardiovascular drugs.
• Asymmetric Synthesis: Used as an electrophile in nucleophilic ring-opening reactions to construct enantiomerically pure 1,2-amino alcohols and 1,2-diols.
• Agrochemical Research: Serves as a building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Material Science: Potential monomer or cross-linking agent for creating advanced polymers with specific optical or mechanical properties.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules in a stereospecific manner for mechanistic studies.

Basic Information

Product Name	(S)-(+)-Glycidyl-4-Nitrobenzenesulfonate
CAS No.	118712-60-0
Molecular Formula	C9H9NO6S
Molecular Weight	259.24 g/mol
Synonyms	(S)-(+)-Glycidyl 4-nitrobenzenesulfonate; (S)-Glycidyl tosylate analog; (S)-Epoxypropyl 4-nitrobenzenesulfonate; (2S)-(-)-1,2-Epoxy-3-[(4-nitrophenyl)sulfonyl]oxy]propane; (S)-(-)-Glycidyl nosylate; 4-Nitrobenzenesulfonic acid (S)-glycidyl ester; (S)-Glycidyl 4-nitrobenzene-1-sulfonate
EINECS	Contact for details

Quality Control

Our (S)-(+)-Glycidyl-4-Nitrobenzenesulfonate is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the rigorous demands of research and process chemistry. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.