Description

Hexakis-6-(Dimethyl-tert-Butylsilyl)-α-Cyclodextrin is a highly functionalized, silylated derivative of α-cyclodextrin designed for advanced applications in supramolecular chemistry and analytical science. This compound matters for its enhanced solubility in organic solvents and its ability to form stable, selective inclusion complexes with a wide range of guest molecules, offering superior performance over native cyclodextrins. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for chiral separation, catalysis, and as a building block for sophisticated molecular hosts.

Application

• Chiral Stationary Phases (CSPs): A key component for high-performance liquid chromatography (HPLC) columns used in the enantiomeric separation and purification of pharmaceutical intermediates and active ingredients.
• Catalysis & Synthesis: Acts as a molecular receptor or catalyst in organic synthesis to enhance reaction selectivity, yield, and regioselectivity.
• Drug Delivery & Formulation: Used in pre-formulation studies to improve the solubility, stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Sensor Development: Serves as a recognition element in chemical sensors and assays for the selective detection of specific analytes, including environmental pollutants.
• Material Science: A precursor for constructing advanced functional materials, such as molecularly imprinted polymers (MIPs) and porous organic frameworks.
• Agrochemical Research: Employed in the study of controlled release formulations for pesticides and herbicides to improve efficacy and reduce environmental impact.

Basic Information

Product Name	Hexakis-6-(Dimethyl-tert-Butylsilyl)-α-Cyclodextrin
CAS No.	118646-79-0
Molecular Formula	C90H180O30Si6
Molecular Weight	~1900.0 g/mol
Synonyms	Per(6-O-tert-Butyldimethylsilyl)-α-Cyclodextrin; Heptakis(6-O-(tert-butyldimethylsilyl))-α-cyclodextrin; α-Cyclodextrin, hexakis(6-O-(1,1-dimethylethyl)dimethylsilyl) ether; Hexakis(6-O-tert-butyldimethylsilyl)-α-CD; TBDMS-α-Cyclodextrin; Silylated α-Cyclodextrin; 6I,II,III,IV,V,VI-O-(tert-Butyldimethylsilyl)-α-cyclodextrin
EINECS	Contact for details

Quality Control

Our Hexakis-6-(Dimethyl-tert-Butylsilyl)-α-Cyclodextrin is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and structural confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture uptake, which can affect performance and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.