Description

Cyclopropanecarboxylic Acid, 2-Methyl-2-Nitro-, trans- (9Ci) is a specialized chiral building block featuring a nitro-substituted cyclopropane ring system, a structure of significant interest in advanced organic synthesis. Its value lies in providing a rigid, three-dimensional scaffold with multiple functional handles for constructing complex molecules with precise stereochemistry. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly those requiring constrained, three-dimensional architectures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyclopropane moiety can enhance biological activity and stability.
• Medicinal Chemistry: Serves as a versatile building block in drug discovery programs for creating focused libraries and probing structure-activity relationships (SAR).
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules containing functionalized cyclopropane units.
• Asymmetric Synthesis: Utilized in stereoselective transformations to introduce quaternary stereocenters and complex molecular frameworks.
• Chemical Research: Acts as a model compound in methodological studies involving nitroalkanes and strained ring systems.

Basic Information

Item	Detail
Product Name	Cyclopropanecarboxylic Acid, 2-Methyl-2-Nitro-, trans- (9Ci)
CAS No.	117078-04-3
Molecular Formula	C6H9NO4
Molecular Weight	159.14 g/mol
Synonyms	trans-2-Methyl-2-nitrocyclopropanecarboxylic Acid; (1R,2S)-2-Methyl-2-nitrocyclopropanecarboxylic Acid (and its enantiomer); 2-Nitro-2-methylcyclopropanecarboxylic acid, trans-; NSC 405124; (1S,2R)-rel-2-Methyl-2-nitrocyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Methyl-2-Nitro-, trans- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC or NMR), chiral purity, and relevant physical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound may be sensitive to prolonged exposure to heat and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.