Description

2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl β-D-Glucopyranosiduronic Acid Methyl Ester is a high-purity, synthetic organic compound of significant interest in advanced pharmaceutical research and development. This specialized chemical serves as a critical intermediate or reference standard in the synthesis and metabolic study of bioactive coumarin derivatives. It is primarily required by research institutions and pharmaceutical companies engaged in developing novel therapeutic agents, particularly those exploring anticoagulant, anti-inflammatory, or antimicrobial pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel coumarin-based drug candidates with potential anticoagulant or anti-inflammatory properties.
• Metabolite Reference Standard: Used in analytical laboratories for the identification and quantification of glucuronidated metabolites in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Biochemical Research: Employed in enzymatic studies, particularly those involving glucuronosyltransferases, to investigate drug metabolism pathways.
• Analytical Chemistry: Serves as a high-purity calibration standard for HPLC, LC-MS, and other chromatographic methods in method development and validation.
• Chemical Synthesis: Advanced starting material for the preparation of more complex, fluorinated heterocyclic compounds for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl β-D-Glucopyranosiduronic Acid Methyl Ester
CAS No.	116523-83-2
Molecular Formula	C₁₇H₁₅F₃O₉
Molecular Weight	444.29 g/mol
Synonyms	7-Hydroxy-4-(trifluoromethyl)coumarin 7-glucuronide methyl ester; 4-Trifluoromethylumbelliferyl-β-D-glucuronide methyl ester; HFC-7-GlcUMe; Methyl (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((7-hydroxy-4-(trifluoromethyl)-2-oxo-2H-chromen-8-yl)oxy)tetrahydro-2H-pyran-2-carboxylate; 4-Trifluoromethyl-7-hydroxycoumarin glucuronide methyl ester; TFMU-GlcU methyl ester; Coumarin glucuronide derivative
EINECS	Contact for details

Quality Control

Our 2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl β-D-Glucopyranosiduronic Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, identity confirmation (IR, NMR), and impurity profiles. Our quality system is designed to support GLP (Good Laboratory Practice) and research-grade standards, ensuring reliable and reproducible results for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.