Description

L-Proline, 3-Hydroxy-5-Methyl-, Methyl Ester, (2Alpha,3Beta,5Beta)- (9Ci) is a specialized, high-purity proline derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its precise stereochemistry and functional groups make it invaluable for constructing complex molecular architectures with high enantiomeric purity. This compound is essential for research and development in the pharmaceutical and agrochemical sectors, particularly for the synthesis of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, especially in oncology, neurology, and metabolic disease research.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with specific chiral activity.
• Asymmetric Catalysis & Ligand Design: Employed in the development of novel chiral catalysts and ligands for stereoselective transformations.
• Academic & Industrial R&D: A valuable tool for medicinal chemists and synthetic organic chemists exploring new chemical spaces and reaction pathways.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	L-Proline, 3-Hydroxy-5-Methyl-, Methyl Ester, (2Alpha,3Beta,5Beta)- (9Ci)
CAS No.	114718-40-0
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	(2S,3R,5S)-3-Hydroxy-5-methylproline methyl ester; Methyl (2S,3R,5S)-3-hydroxy-5-methylprolinate; L-3-Hydroxy-5-methylproline methyl ester; (2α,3β,5β)-3-Hydroxy-5-methyl-L-proline methyl ester; Proline, 3-hydroxy-5-methyl-, methyl ester, (2α,3β,5β)- (9CI)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of L-Proline, 3-Hydroxy-5-Methyl-, Methyl Ester is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. We adhere to strict in-process controls and final release specifications. Certificates of Analysis (COA) detailing all relevant parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.