Description

Milbemycin B, 5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-(Methoxyimino)-25-(1-Methyl-1-Propenyl)-, [6R,23E,25S(E)]- (9Ci) is a key semi-synthetic intermediate derived from the natural milbemycin family of 16-membered macrolides. This compound is of significant commercial and research interest for the development of novel, high-potency acaricides and anthelmintics. It is primarily utilized by agrochemical and pharmaceutical R&D teams, as well as by manufacturers of active pharmaceutical ingredients (APIs) and veterinary medicines seeking to develop next-generation parasitic control agents.

Application

• Agrochemical Intermediate: Critical precursor in the synthesis of advanced milbemycin-based acaricides and nematicides for crop protection.
• Veterinary Pharmaceutical R&D: Serves as a building block for developing novel endectocides and anthelmintics for livestock and companion animals.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production of high-purity APIs for antiparasitic formulations.
• Chemical Reference Standard: Employed as a certified reference material (CRM) for analytical method development and quality control in manufacturing.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry research to explore new derivatives with improved efficacy and safety profiles.
• Biochemical Research: Used in studies investigating the mode of action of macrocyclic lactones on invertebrate glutamate-gated chloride channels.

Basic Information

Product Name	Milbemycin B, 5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-(Methoxyimino)-25-(1-Methyl-1-Propenyl)-, [6R,23E,25S(E)]- (9Ci)
CAS No.	114041-32-6
Molecular Formula	C₃₆H₅₃NO₇
Molecular Weight	611.82 g/mol
Synonyms	5-O-Demethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-[(1E)-1-methyl-1-propen-1-yl]milbemycin B; 23-(Methoxyimino)milbemycin B derivative; LL-F28249-λ; Nemadectin intermediate; [6R-[6R*,23E,25S*(E)]]-5-O-Demethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-(1-methyl-1-propenyl)milbemycin B; (9CI) Milbemycin B derivative; 23-Methoxyiminomilbemycin B
EINECS	Contact for details

Quality Control

Our Milbemycin B derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for advanced chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support compliance with cGMP standards for pharmaceutical intermediates and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storage under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.