Description

1-Bromo-4-(Chloromethyl)-2-Methoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists for applications in medicinal chemistry, material science, and the synthesis of fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing substituted benzyl or aryl ether motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where its halogen and methoxy groups enable further functionalization.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers.
• Fine Chemical Production: Acts as a building block for dyes, pigments, and other specialty chemicals requiring specific aromatic substitution patterns.
• Cross-Coupling Reactions: The bromine and chloromethyl groups make it a valuable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed transformations.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2-Methoxybenzene
CAS No.	113081-49-5
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	4-Bromo-3-methoxybenzyl chloride; 2-Methoxy-4-bromobenzyl chloride; 1-Bromo-4-(chloromethyl)-2-methoxybenzene; (4-Bromo-3-methoxyphenyl)methyl chloride; 4-Bromo-3-methoxybenzylchloride; 4-Bromo-3-methoxybenzyl Chloride; 4-Bromo-3-methoxybenzylchloride; 4-Bromo-3-methoxybenzyl chloride
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Chloromethyl)-2-Methoxybenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.