Description

1-Bromo-4-[Chloro(Difluoro)Methoxy]Benzene is a specialized halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of bromine, chlorine, and fluorine substituents, which allows for selective functionalization and the introduction of lipophilicity and metabolic stability into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Research: An important compound for studying the effects of multiple halogens, including fluorine, on aromatic system reactivity and physical properties.
• Chemical Intermediate for Dyes & Pigments: Can be utilized to synthesize complex halogenated aromatic structures for specialized colorants.

Basic Information

Product Name	1-Bromo-4-[Chloro(Difluoro)Methoxy]Benzene
CAS No.	112556-13-5
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	4-Bromo-1-[chloro(difluoro)methoxy]benzene; p-Bromophenyl chlorodifluoromethyl ether; Benzene, 1-bromo-4-[chloro(difluoro)methoxy]-; 1-Bromo-4-(chlorodifluoromethoxy)benzene; 4-Bromo(chlorodifluoromethoxy)benzene; Bromo(chlorodifluoromethoxy)benzene; Chlorodifluoro(4-bromophenoxy)methane
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-[Chloro(Difluoro)Methoxy]Benzene is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.