Description

Heptakis-(2,6-Di-O-ethyl)-β-cyclodextrin is a chemically modified derivative of β-cyclodextrin, specifically engineered with ethyl groups at the 2 and 6 positions of each glucose unit. This modification is critical as it significantly enhances the compound's solubility in organic solvents and alters its host-guest complexation properties compared to the native cyclodextrin. It is an essential advanced material for researchers and formulators in the pharmaceutical and chemical industries who require precise molecular encapsulation to improve drug solubility, stability, and bioavailability. Its unique structure makes it a valuable tool for chiral separation, catalysis, and the development of advanced delivery systems.

Application

• Pharmaceutical Research & Development: As a solubility enhancer and stabilizer for poorly water-soluble active pharmaceutical ingredients (APIs) in pre-formulation studies.
• Chiral Separation: Utilized as a chiral stationary phase additive or mobile phase modifier in High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE) for the resolution of enantiomers.
• Drug Delivery Systems: A key component in the design of novel drug delivery carriers, including nanoparticles, liposomes, and hydrogels, to control drug release.
• Catalysis & Organic Synthesis: Acts as a supramolecular catalyst or reaction medium modifier to influence reaction rates, selectivity, and yields in synthetic chemistry.
• Flavor & Fragrance Encapsulation: Used to complex, protect, and control the release of sensitive flavor and fragrance compounds in food and cosmetic applications.
• Analytical Chemistry: Serves as a complexing agent in analytical methods for the selective extraction, preconcentration, or sensing of specific molecules.

Basic Information

Product Name	Heptakis-(2,6-Di-O-ethyl)-β-cyclodextrin
CAS No.	111689-03-3
Molecular Formula	C56H98O35
Molecular Weight	1331.37 g/mol
Synonyms	2,6-Di-O-ethyl-β-cyclodextrin; Heptakis(2,6-di-O-ethyl)-β-cyclodextrin; DEE-β-CD; Ethylated β-cyclodextrin; β-Cyclodextrin, 2,6-di-O-ethyl-; Per(2,6-di-O-ethyl)-β-cyclodextrin; 2,6-Diethyl-β-cyclodextrin; E457
EINECS	Contact for details

Quality Control

Our Heptakis-(2,6-Di-O-ethyl)-β-cyclodextrin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Specifications typically include assay by HPLC, residual solvent analysis, and confirmation of substitution degree. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which may affect performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Degree of Substitution (DS)	~14 (Theoretical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.