Description

7-Chloro-6-Fluoro-4-Hydroxy-2-Methylchroman-4-Acetic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory and other therapeutic agents. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules targeting specific biological pathways.
• Anti-inflammatory Drug Research: Serves as a core scaffold for the development of new non-steroidal anti-inflammatory drugs (NSAIDs) and related therapeutic candidates.
• Custom Chemical Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and process development.
• Chemical Reference Standard: Employed as a high-purity standard in analytical method development and quality control laboratories for API characterization.
• Medicinal Chemistry: Provides a versatile chroman-acetic acid framework for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	7-Chloro-6-Fluoro-4-Hydroxy-2-Methylchroman-4-Acetic Acid
CAS No.	111477-47-5
Molecular Formula	C₁₂H₁₀ClFO₄
Molecular Weight	272.66 g/mol
Synonyms	4-Acetic Acid-7-chloro-6-fluoro-4-hydroxy-2-methylchroman; 7-Chloro-6-fluoro-4-hydroxy-2-methyl-4-chromaneacetic acid; 2-Methyl-7-chloro-6-fluoro-4-hydroxy-chroman-4-acetic acid; Chroman-4-acetic acid, 7-chloro-6-fluoro-4-hydroxy-2-methyl-; 4-Hydroxy-7-chloro-6-fluoro-2-methylchroman-4-acetic Acid; 7-Chloro-6-fluoro-4-hydroxy-2-methyl-3,4-dihydro-2H-1-benzopyran-4-acetic acid
EINECS	Contact for details

Quality Control

Our 7-Chloro-6-Fluoro-4-Hydroxy-2-Methylchroman-4-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.