Description

5-(Trifluoromethyl)Chroman-4-One is a versatile fluorinated organic building block characterized by its chromanone core and trifluoromethyl substituent. This compound is of significant commercial interest due to its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Employed in the design of fluorinated probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-(Trifluoromethyl)Chroman-4-One
CAS No.	111141-06-1
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	5-(Trifluoromethyl)-4-chromanone; 5-(Trifluoromethyl)-2,3-dihydro-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 5-(trifluoromethyl)-2,3-dihydro-; Chroman-4-one, 5-(trifluoromethyl)-; 111141-06-1
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Chroman-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.