Description

Tos-D-Pro-Oh CAS NO 110771-95-4 is a high-purity, protected amino acid derivative, specifically the tosyl (Tos) derivative of D-Proline. This compound is a critical chiral building block in modern organic synthesis, valued for its role in constructing complex molecular architectures with precise stereochemistry. It is essential for research and production in the pharmaceutical and biotechnology sectors, particularly for the development of peptide-based therapeutics, enzyme inhibitors, and advanced materials.

Application

• Peptide Synthesis: A key chiral intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs), especially those targeting neurological and metabolic disorders.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Bioconjugation: Employed in the design and synthesis of peptide-drug conjugates and other bioconjugates for targeted drug delivery.
• Chemical Biology Research: A valuable tool for studying enzyme-substrate interactions and for the development of protease inhibitors.
• Material Science: Used in the synthesis of specialty polymers and foldamers with unique structural properties.

Basic Information

Product Name	Tos-D-Pro-Oh
CAS No.	110771-95-4
Molecular Formula	C₁₂H₁₅NO₄S
Molecular Weight	269.32 g/mol
Synonyms	(R)-1-[(4-Methylphenyl)sulfonyl]pyrrolidine-2-carboxylic acid; D-Proline, N-tosyl-; N-Tosyl-D-proline; N-p-Tosyl-D-proline; D-N-Tosylproline; (R)-N-Tosylproline; (R)-1-Tosylpyrrolidine-2-carboxylic acid; Tos-D-Pro-OH
EINECS	Contact for details

Quality Control

Our Tos-D-Pro-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical research and development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.