Description

Ethyl 5-Hydroxy-Tetrahydro-Pyran-2-Carboxylate is a high-purity chiral building block and ester derivative of a functionalized tetrahydropyran. This compound matters for its role as a versatile synthetic intermediate in the production of complex pharmaceutical molecules and fine chemicals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce a hydroxy-tetrahydropyran moiety into target structures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, or central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the tetrahydropyran scaffold contributes to biological activity.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other specialty organic compounds requiring a protected or functionalized sugar-like moiety.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis, including asymmetric catalysis and cyclization studies.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique solubility or degradation profiles.

Basic Information

Product Name	Ethyl 5-Hydroxy-Tetrahydro-Pyran-2-Carboxylate
CAS No.	110407-58-4
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	Ethyl 5-hydroxytetrahydro-2H-pyran-2-carboxylate; 5-Hydroxytetrahydro-2H-pyran-2-carboxylic acid ethyl ester; 2H-Pyran-2-carboxylic acid, 5-hydroxyhexahydro-, ethyl ester; Ethyl 5-hydroxytetrahydropyran-2-carboxylate; 5-Hydroxy-tetrahydropyran-2-carboxylic acid ethyl ester; Ethyl (5R/S)-5-hydroxytetrahydropyran-2-carboxylate (racemic mixture); THP-protected glycolate ethyl ester derivative.
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-Tetrahydro-Pyran-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.