Description

(S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione is a high-purity, chiral organic compound characterized by its complex fused-ring indolizine structure. This compound serves as a critical advanced intermediate in the synthesis of complex pharmaceuticals and bioactive molecules, where its stereochemistry is essential for biological activity. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, especially those targeting neurological or metabolic pathways.
• Asymmetric Synthesis: Used in the development of novel catalysts and ligands for stereoselective chemical transformations.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Biochemical Probes: Potential use in developing probes for studying enzyme mechanisms or biological pathways due to its unique heterocyclic structure.
• Fine Chemical Synthesis: Intermediate for the production of other complex, high-value specialty chemicals and natural product analogs.

Basic Information

Product Name	(S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione
CAS No.	110351-94-5
Molecular Formula	C₁₃H₁₃NO₅
Molecular Weight	263.25 g/mol
Synonyms	(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H,4H-pyrano[3,4-f]indolizine-3,6,10-trione; 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, (S)-; Swainsonine derivative intermediate; Pyranoindolizinetrione derivative
EINECS	Contact for details

Quality Control

Our (S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.