Description

(R)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused-ring indolizine structure. This compound is of significant commercial interest for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological or metabolic pathways.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct stereochemically defined molecular architectures.
• Medicinal Chemistry Research: Employed in R&D for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules with the indolizine core.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for potential APIs in pilot plants and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione
CAS No.	110351-91-2
Molecular Formula	C₁₃H₁₃NO₅
Molecular Weight	263.25 g/mol
Synonyms	(4R)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (R)-4-Ethyl-4-hydroxy-7,8-dihydro-1H,4H-pyrano[3,4-f]indolizine-3,6,10-trione; 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, (R)-; CAS 110351-91-2; Pyrano[3,4-f]indolizine trione derivative
EINECS	Contact for details

Quality Control

Our (R)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-F]Indolizine-3,6,10(4H)-Trione is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.