Description

(S)-3-[[(1,1-Dimethyl)Dimethylsily]Oxy]Pentanedioic Acid Monomethyl Ester is a high-value chiral synthon and protected derivative of glutamic acid, featuring a silyl-protected hydroxyl group. This compound is critical for synthetic chemists as it provides a versatile, enantiomerically pure building block for the controlled synthesis of complex molecules, particularly in pharmaceutical research. It is primarily needed by R&D laboratories and production facilities in the fine chemical and pharmaceutical industries for developing active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used in the design and synthesis of peptide analogs and conformationally constrained amino acid derivatives.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective reactions to construct molecules with defined chirality.
• Prodrug Development: Utilized in creating protected or esterified forms of amino acids for improved drug delivery and stability.
• Bioconjugation Chemistry: The reactive ester and protected hydroxyl group enable its use in linking molecules for chemical biology applications.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	(S)-3-[[(1,1-Dimethyl)Dimethylsily]Oxy]Pentanedioic Acid Monomethyl Ester
CAS No.	109721-08-6
Molecular Formula	C11H22O5Si
Molecular Weight	262.38 g/mol
Synonyms	(S)-3-[(tert-Butyldimethylsilyl)oxy]glutaric acid monomethyl ester; (S)-3-[(TBDMS)oxy]glutaric acid 1-methyl ester; (S)-Methyl 3-[(tert-butyldimethylsilyl)oxy]pentanedioate; (S)-3-(tert-Butyldimethylsiloxy)glutaric acid methyl ester; (S)-3-(TBDMSO)glutaric acid monomethyl ester; (S)-Mono-methyl 3-(tert-butyldimethylsilyloxy)glutarate; (S)-3-Hydroxyglutaric acid 1-methyl ester 3-(tert-butyldimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our (S)-3-[[(1,1-Dimethyl)Dimethylsily]Oxy]Pentanedioic Acid Monomethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.