Description

4-Acetylphenyl Triflate is a high-value trifluoromethanesulfonate (triflate) ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in its exceptional reactivity as a leaving group, enabling efficient cross-coupling reactions and functional group transformations that are difficult to achieve with other reagents. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to construct complex molecular architectures with high precision and yield.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heteroaryl systems via Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the introduction of acetylphenyl motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Catalysis & Ligand Development: Employed in the preparation of sophisticated organometallic catalysts and phosphine ligands for asymmetric synthesis.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for methodology development and exploring new reaction pathways.
• Fine Chemical Production: Facilitates the manufacture of complex fragrance and dye intermediates where selective functionalization is required.

Basic Information

Product Name	4-Acetylphenyl Triflate
CAS No.	109613-00-5
Molecular Formula	C9H7F3O4S
Molecular Weight	268.21 g/mol
Synonyms	1-[4-[(Trifluoromethyl)sulfonyl]oxy]phenyl]ethanone; 4-Acetylphenyl Trifluoromethanesulfonate; p-Acetylphenyl Triflate; Trifluoromethanesulfonic Acid 4-Acetylphenyl Ester; 4-Acetylphenyl Trifluoromethanesulphonate; 4-Acetylphenyl Triflate Ester; (4-Acetylphenyl) Triflate; 4-Acetyl Phenyl Triflate
EINECS	Contact for details

Quality Control

Our 4-Acetylphenyl Triflate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced chemical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.