Description

1-(4,5-Dihydrofuran-3-Yl)-2,2,2-Trifluoroethan-1-One is a specialized trifluoromethyl ketone derivative, a high-value building block prized for its unique reactivity profile. Its core value lies in introducing the trifluoroacetyl group into complex molecular architectures, a critical step in developing compounds with enhanced metabolic stability and bioavailability. This intermediate is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethyl group for improved pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and manufacture of advanced herbicides, fungicides, and insecticides where the CF3 moiety enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for novel polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Fluorine Chemistry: A versatile reagent in organofluorine chemistry for constructing complex fluorinated heterocycles and fine chemicals.
• Cross-Coupling Reactions: Acts as an electrophile in various metal-catalyzed cross-coupling reactions to form carbon-carbon bonds in complex molecule assembly.

Basic Information

Product Name	1-(4,5-Dihydrofuran-3-Yl)-2,2,2-Trifluoroethan-1-One
CAS No.	109317-75-1
Molecular Formula	C7H7F3O2
Molecular Weight	180.13 g/mol
Synonyms	3-(Trifluoroacetyl)-2,3-dihydrofuran; 2,3-Dihydro-3-furanyl trifluoromethyl ketone; 1-(2,3-Dihydro-3-furanyl)-2,2,2-trifluoroethanone; 2,3-Dihydrofuran-3-yl trifluoromethyl ketone; 3-Trifluoroacetyl-2,3-dihydrofuran; Trifluoro(2,3-dihydro-3-furanyl)methanone; 3-(2,2,2-Trifluoroacetyl)-2,3-dihydrofuran
EINECS	Contact for details

Quality Control

Our 1-(4,5-Dihydrofuran-3-Yl)-2,2,2-Trifluoroethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.