Description

(+)-2,3-o-Isopropylidene-D-Threitol 1,4-Dimethane Sulfonate is a high-purity, chiral building block and key pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of nucleoside analogs and other active pharmaceutical ingredients (APIs). It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries where precise stereochemistry and high chemical purity are critical.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecules with defined stereocenters for drug discovery.
• Protecting Group Chemistry: The isopropylidene group serves as a protective moiety for diols in multi-step organic syntheses.
• Chemical Research: Employed in academic and industrial R&D for developing new synthetic methodologies and novel chemical entities.
• Process Chemistry: Used in scale-up and optimization of manufacturing routes for high-value fine chemicals and APIs.
• Bioconjugation: Potential use in modifying biomolecules due to the reactive dimethanesulfonate groups.

Basic Information

Product Name	(+)-2,3-o-Isopropylidene-D-Threitol 1,4-Dimethane Sulfonate
CAS No.	109281-59-6
Molecular Formula	C10H18O8S2
Molecular Weight	330.37 g/mol
Synonyms	D-Threitol, 1,2:3,4-di-O-isopropylidene-, 1,4-bis(methanesulfonate); (3aR,6aR)-2,2-Dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4,6-diyl bis(methanesulfonate); 1,2:3,4-Di-O-isopropylidene-D-threitol 1,4-Dimethanesulfonate; (3aR,6aR)-Hexahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4,6-diyl Dimethanesulfonate; D-1,2:3,4-Diisopropylidene Threitol 1,4-Dimesylate
EINECS	Contact for details

Quality Control

Our (+)-2,3-o-Isopropylidene-D-Threitol 1,4-Dimethane Sulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and chiral purity analysis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.