Description

n-(2,4,6-Triisopropylphenylsulfonyl)Tryptophan is a specialized, high-purity sulfonamide derivative of the essential amino acid tryptophan. This compound serves as a critical building block and protecting group reagent in advanced organic synthesis, particularly for peptide chemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic peptides and complex organic molecules.

Application

• Peptide Synthesis: Acts as a key intermediate or a protecting group reagent for the tryptophan residue during solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Research: Serves as a building block in the research and development of new drug candidates, especially those targeting neurological and oncological pathways.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other bioconjugates where specific, stable linkages are required.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides and molecular probes for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry Development: Utilized in scaling up synthetic routes for complex molecules in pilot plants and commercial manufacturing.
• Academic Research: A valuable reagent for universities and research institutes exploring novel synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	n-(2,4,6-Triisopropylphenylsulfonyl)Tryptophan
CAS No.	108325-64-0
Molecular Formula	C26H35NO4S
Molecular Weight	457.63 g/mol
Synonyms	N-[(2,4,6-Triisopropylphenyl)sulfonyl]-L-tryptophan; Trtps; TIPS-Trp-OH; N-Tipsyl-L-tryptophan; L-Tryptophan, N-[(2,4,6-triisopropylphenyl)sulfonyl]-; N-(2,4,6-Triisopropylbenzenesulfonyl)tryptophan; 2,4,6-Triisopropylbenzenesulfonyl tryptophan
EINECS	Contact for details

Quality Control

Our n-(2,4,6-Triisopropylphenylsulfonyl)Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the exacting standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.