Description

Methanesulfonic Acid, Trifluoro-, 2-Hydroxyethyl Ester is a specialized fluorinated sulfonate ester, a high-value intermediate in advanced chemical synthesis. Its unique structure, featuring both a reactive ester group and electron-withdrawing trifluoromethyl moiety, makes it a critical building block for creating compounds with enhanced stability and performance. This product is essential for R&D and production in the pharmaceutical and agrochemical sectors, where it is used to introduce the trifluoromethanesulfonate (triflate) group, a superior leaving group for cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing triflate groups in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi).
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides that benefit from the metabolic stability imparted by the fluorine atoms.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization.
• Material Science: Employed in the production of specialty polymers, liquid crystals, and electronic chemicals where fluorinated components are required for thermal, chemical, or optical properties.
• Organic Synthesis Reagent: Acts as a versatile triflating agent for converting alcohols and phenols into their corresponding triflates, which are highly reactive electrophiles.

Basic Information

Product Name	Methanesulfonic Acid, Trifluoro-, 2-Hydroxyethyl Ester
CAS No.	108286-01-7
Molecular Formula	C3H5F3O4S
Molecular Weight	194.13 g/mol
Synonyms	2-Hydroxyethyl Trifluoromethanesulfonate; Ethylene Glycol Triflate; Trifluoromethanesulfonic Acid 2-Hydroxyethyl Ester; 2-(Trifluoromethanesulfonyloxy)ethanol; HOETf; 2-Hydroxyethyl Triflate; Triflic Acid 2-Hydroxyethyl Ester; Glycol Triflate
EINECS	Contact for details

Quality Control

Our Methanesulfonic Acid, Trifluoro-, 2-Hydroxyethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Store away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.