Description

Methyl H-Pyrrolo[1,2-B]Pyridazine-6-Carboxylate CAS NO 108128-21-8 is a high-purity, advanced pharmaceutical intermediate belonging to the fused heterocyclic pyridazine class. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug molecules, especially those with fused heterocyclic scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Oncology Drug Development: A crucial component in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the creation of novel compounds for neurological and psychiatric disorder research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical candidates.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and methodology development.

Basic Information

Product Name	Methyl H-Pyrrolo[1,2-B]Pyridazine-6-Carboxylate
CAS No.	108128-21-8
Molecular Formula	C9H8N2O2
Molecular Weight	176.17 g/mol
Synonyms	Methyl 1H-Pyrrolo[1,2-b]pyridazine-6-carboxylate; Methyl 1H-Pyrrolo[1,2-b]pyridazine-6-carboxylate; 1H-Pyrrolo[1,2-b]pyridazine-6-carboxylic acid, methyl ester; Methyl pyrrolo[1,2-b]pyridazine-6-carboxylate; 6-Methoxycarbonyl-1H-pyrrolo[1,2-b]pyridazine
EINECS	Contact for details

Quality Control

Our production of Methyl H-Pyrrolo[1,2-B]Pyridazine-6-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines where required for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.