Description

n-Succinimidyl 4-(Tri-n-Butylstannyl)Benzoate is a specialized organotin reagent designed for efficient bioconjugation and labeling applications. Its core value lies in its dual functionality, combining an amine-reactive N-hydroxysuccinimide (NHS) ester with a versatile organotin moiety, enabling stable cross-linking and subsequent Stille coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, bioconjugate chemistry, and advanced materials science, where precise and stable modification of biomolecules is required.

Application

• Bioconjugation and Protein Labeling: The NHS ester group facilitates covalent attachment to primary amines on proteins, antibodies, and peptides, introducing a tin handle for further functionalization.
• Radiopharmaceutical Precursor: Serves as a key intermediate in the synthesis of radioiodinated or radiostannylated compounds for diagnostic imaging and targeted radiotherapy.
• Polymer and Materials Functionalization: Used to modify polymer backbones or nanoparticle surfaces with organotin groups, enabling subsequent cross-coupling to install fluorescent dyes, targeting ligands, or other functional units.
• Stille Cross-Coupling Reactions: The tri-n-butylstannyl group acts as a robust coupling partner in palladium-catalyzed Stille reactions to form new carbon-carbon bonds, useful in complex molecule synthesis.
• Development of Diagnostic Assays: Employed in creating labeled probes and reagents for immunoassays, fluorescence in situ hybridization (FISH), and other detection platforms.
• Linker Chemistry in Drug Discovery: Facilitates the construction of antibody-drug conjugates (ADCs) and other targeted therapeutic agents by providing a stable, cleavable, or non-cleavable linkage.

Basic Information

Product Name	n-Succinimidyl 4-(Tri-n-Butylstannyl)Benzoate
CAS No.	107759-58-0
Molecular Formula	C27H43NO4Sn
Molecular Weight	564.33 g/mol
Synonyms	4-(Tributylstannyl)benzoic acid N-succinimidyl ester; 4-(Tri-n-butylstannyl)benzoic acid N-hydroxysuccinimide ester; NHS-Tin ester; Succinimidyl 4-(tributylstannyl)benzoate; 4-(Tributylstannyl)benzoic acid succinimidyl ester; STB-NHS; N-Succinimidyl-4-(tributylstannyl)benzoate; Tin-NHS ester
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 4-(Tri-n-Butylstannyl)Benzoate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis for tin content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Tin (Sn) Content	20.5% - 21.5%
Solubility	Soluble in DMF, DMSO, THF, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.